Contrasting associations of adiposity with ischaemic stroke and intracerebral haemorrhage

May 16, 2018 3:46 PM

A new study from the China Kadoorie Biobank, published in the Lancet Global Health, has examined the association of adiposity with the risk of stroke types, and the mediating effect of blood pressure on these associations.

Adiposity was strongly positively associated with ischaemic stroke (IS), generally consistent with the expected associations of adiposity with SBP and of SBP with IS. However, individuals with higher levels of adiposity were found to have risk of intracerebral haemorrhage (ICH) much lower than that predicted by these two associations, and after adjustment for SBP the association was reversed. These unexpected, and currently unexplained, findings on ICH suggest that leanness, either per se or through some other factor(s), might increase the risk, and future studies are needed to establish the causal relevance of adiposity for ICH.

Read the full paper here.