Lead by Dr Ling Yang and Dr Iona Millwood the project will start in November 2017. During the first year of project, a custom-designed multiplex serology panel will be designed by CKB investigators and collaborators from the German Cancer Research Centre (DKFZ) and IARC, this will then be developed and validated in the lab. The study samples will be selected using a rigid study case-cohort study design. Four thousand samples will be assayed using the above multiplex panel to detect and quantify 15 H. pylori antigens and multiple other infectious pathogens (e.g. EBV, HPV, HBV and HCV) relevant to gastrointestinal cancer and other diseases.
This will be the largest single study to evaluate the role of H. pylori and other infectious pathogens, and their interactions with lifestyle and dietary risk factors, in the aetiology of gastric and oesophageal cancer subtypes.