Evaluation of type 2 diabetes risk variants published in Diabetologia

Apr 14, 2016 3:05 PM

The individual and cumulative effects of 59 established type 2 diabetes risk loci were measured and assessed in 93,000 CKB participants.

Genome-wide association studies (GWAS) have discovered many risk variants for type 2 diabetes. However, estimates of the contributions of risk variants to type 2 diabetes predisposition are often based on highly selected case–control samples, and reliable estimates of population-level effect sizes are missing, especially in non-European populations.

This study provides further evidence of shared genetic architecture for type 2 diabetes between Europeans and East Asians. It also indicates that even very large GWAS meta-analyses may be vulnerable to substantial inflation of effect size estimates, compared with those observed in large-scale population-based cohort studies.

Read the full paper here.