The SNPs were selected based on association with a range of chronic diseases (e.g. stroke, IHD, diabetes) and related phenotypes (e.g. blood pressure, adiposity, lung function) in previous large studies. Analyses in CKB participants will focus on using SNPs as tools to evaluate the causal relevance of risk factors for chronic diseases. For example a risk score consisting of SNPs associated with blood pressure can be used to evaluate the causal effect of blood pressure in different stroke subtypes.