The CTSU Wolfson laboratories provide critical and cost-effective support for large-scale observational studies (involving up to 0.5 million people) and randomised trials (involving up to 30,000 participants) conducted by the CTSU and collaborating research groups.
A number of specialist and platform technologies are supported by the laboratories including; clinical chemistry, HPLC, haematology and immunoassay. In addition, automated liquid handling workstations support array-plate work and sample reformatting. Future capacity will include a nuclear magnetic resonance (NMR) metabolomics facility which is due to be operational Spring 2015.
The laboratories are accredited to the international standard ISO 17025:2005 ‘General requirements for the competence of testing and calibration laboratories’ as a testing laboratory.
Scientific investigation and guidance: The CTSU Wolfson laboratories investigate, and provide guidance for, various methodological aspects such as: sample collection (blood, urine) and transport procedures; stability of biomarkers; cataloguing and storage strategies for large-scale collections; and the development of analytical methods suitable for high-throughput testing in large study populations (without compromising reliability or quality of data produced).
Routine analyses: Many clinical chemistry tests are run routinely; including lipids, enzymes, glycosylated haemoglobin A1C, urinary micro-albumin and creatinine. In addition, the laboratories have considerable experience across a range of other assays including; proteins, haematological parameters, hormones, electrolytes, vitamins (lipid and water soluble) and specialist and plate-array methods (for example; a semi-quantitative cotinine assay, multi-plex assays etc).