Annual CKB Research Day

The CKB held its annual event to showcase the resource on the 4th April 2017.

 

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Smoking set to kill one in three young men in China

Two-thirds of the young men in China start to smoke, mostly before age 20. A CKB led study published in The Lancet shows that around half of those who start smoking cigarettes as young men will eventually be killed by tobacco, unless they stop permanently. The results show that in China the annual number of tobacco deaths, mostly among men, had reached 1 million by 2010, and if current trends continue, it will be 2 million by 2030.

 

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New funding award to investigate pancreatic cancer

Funding has been secured from the Pancreatic Cancer UK - Research Innovation Fund to assist in the development of a blood test for the early detection of pancreatic cancer.

 

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CKB samples move into new purpose-built storage facility in China

The China National Cardiovascular Biocentre has opened in Xi Shan, Beijing. Storage facilities for CKB biological samples include 11 liquid nitrogen tanks, and 35 -80 °C freezers.

 

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Fresh fruit associated with lower risk of diabetes and related complications in Chinese adults

People who often eat fresh fruit are at lower risk of developing diabetes and related major vascular complications than people who rarely eat fruit, according to new research published this week in PLOS Medicine.

 

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Chinese adults with diabetes lose nine years of life.

In China, people with diabetes diagnosed in middle age lose, on average, nine years of life, according to new CKB research published in the January 17 issue of JAMA. This is mainly due to inadequate treatment, particularly in rural areas.

 

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New research award for air pollution project

China Kadoorie Biobank investigators and collaborators have received approximately £600K foundation grant from the Medical Research Council, Global Challenges Research Fund to develop methods that would provide reliable estimates of health effects associated to both household and ambient air pollution.

 

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Smoking associated with higher risk of type 2 diabetes

CKB research published in the Lancet Public Health shows that regular smokers have a 15-30% higher risk of developing diabetes, after taking account of the effects of age, socioeconomic status, alcohol consumption, physical activity and adiposity.

 

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Physical activity associated with lower risk of heart attack and stroke in China

New research published in JAMA Cardiology highlights the health benefits of physical activity including occupation-related activities.

 

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A large genetic study in Chinese adults showed no benefit of raising “good” cholesterol by CETP inhibition

Raising so-called “good” cholesterol by blocking a key protein involved in its metabolism does not protect against heart disease or stroke, according to a large genetic study of 150,000 Chinese adults published this week in JAMA Cardiology.

 

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Household air pollution linked to higher risk of cardiovascular disease

Exposure to household air pollution from using wood or coal for cooking and heating is associated with higher risk of death from heart attack and stroke, according to new CKB research published in JAMA.

 

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Cause-specific mortality and 1st resurvey data now available.

The CKB study group is committed to making the data collected/generated on the cohort available to the scientific community in China, the UK and worldwide and actively engages with collaborators on a range of projects. The CKB Data Access System was launched in 2015, a second tranche of data including details of cause specific mortality coded to ICD-10 and 1st resurvey data is now available for China-based Open Access researchers.

 

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China Kadoorie Biobank

Chronic diseases (e.g. heart attack, stroke, diabetes, and cancer) are the leading causes of death and disability in developed and developing countries. Large blood-based prospective cohort studies can provide reliable assessment of the complex interplay of lifestyle, environmental, and genetic susceptibility as causes of chronic disease. Establishing such a study in China is of particular value, given the large size of its population, its increasing burden of chronic diseases, its unique patterns of disease rates and risk exposures, and the limited evidence from previous studies about the causes of many common chronic conditions in this population.

The China Kadoorie Biobank (CKB), known previously as the Kadoorie Study of Chronic Disease in China (KSCDC), is set up to investigate the main genetic and environmental causes of common chronic diseases in the Chinese population. During 2004-8, over 510,000 adults were recruited from 10 geographically defined regions of China, with extensive data collection by questionnaire and physical measurements, and with long-term storage of blood samples for future study. All the participants are now being closely monitored for death and other health-related outcomes through linkage with established registries and health insurance databases in the study areas. Every few years, periodic re-surveys are also to be conducted in about 25,000 surviving participants, with a repeat interview, measurements and blood collection (as in the baseline survey) to help assess changes of risk exposures in the study population. This large, well-established, study will be a uniquely powerful and rich resource for investigating the main causes of many common chronic diseases over the next few decades, and the information generated will advance our understanding of disease aetiology not only in China but also in other countries.

The CKB is being conducted jointly by University of Oxford’s Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU) and the Chinese Academy of Medical Sciences (CAMS). It was established with funding support to CTSU from the Kadoorie Charitable Foundation (KCF) in Hong Kong. The long-term continuation of the study is supported by the Wellcome Trust, with further support in China from the Chinese Natural Science Foundation and Chinese Ministry of Science and Technology. The UK Medical Research Council (MRC), British Heart Foundation (BHF) and Cancer Research UK (CRUK) also provide core funding to CTSU for the project.